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[Physiological basis of alcohol-induced skeletal muscle injury].

Authors
  • Zinovyeva, O E
  • Emelyanova, A Y
  • Samhaeva, N D
  • Sheglova, N S
  • Shenkman, B S
  • Nemirovskaya, T L
Type
Published Article
Journal
Fiziologiia cheloveka
Publication Date
Jan 01, 2016
Volume
42
Issue
3
Pages
130–136
Identifiers
PMID: 29446911
Source
Medline
Language
Russian
License
Unknown

Abstract

Alcohol-induced muscle damage (AIMD) - an umbrella term that includes all forms of alcoholic myopathy developing in acute or chronic alcohol intoxication. The most common form of destruction of skeletal muscle in alcoholism is a chronic alcoholic myopathy, which develops independently of other manifestations of alcoholism, such as polyneuropathy, malabsorption syndrome, liver damage, but can be combined with them. The basis of the destruction of skeletal muscle in chronic AIPM is atrophy of muscle fibers. Mainly affects muscle fiber type II with less destruction of type ! fibers. Currently, the pathogenesis of chronic alcoholic myopathy is studied. The imbalance of protein synthesis and proteolysisand increased apoptosis rate are discussed.

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