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Physicochemical characterization and in vitro dissolution behaviour of celecoxib-beta-cyclodextrin inclusion complexes.

Authors
  • Sinha, Vivek Ranjan1
  • Anitha, R
  • Ghosh, Soma
  • Amita
  • Kumria, Rachana
  • Bhinge, Jayant Rajaram
  • Kumar, Manoj
  • 1 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. [email protected] , (India)
Type
Published Article
Journal
Acta pharmaceutica (Zagreb, Croatia)
Publication Date
Mar 01, 2007
Volume
57
Issue
1
Pages
47–60
Identifiers
PMID: 19839406
Source
Medline
License
Unknown

Abstract

In this study, attempts were made to investigate the effects of beta-cyclodextrin (beta-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.

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