Physicochemical characterization and in vitro dissolution behaviour of celecoxib-beta-cyclodextrin inclusion complexes.
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. [email protected]
- Published Article
Acta pharmaceutica (Zagreb, Croatia)
- Publication Date
Mar 01, 2007
In this study, attempts were made to investigate the effects of beta-cyclodextrin (beta-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/19839406