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Physical Activity and HIV: Effects on Fitness Status, Metabolism, Inflammation and Immune-Activation.

Authors
  • Ceccarelli, Giancarlo1
  • Pinacchio, Claudia2
  • Santinelli, Letizia3
  • Adami, Paolo Emilio4, 5
  • Borrazzo, Cristian2
  • Cavallari, Eugenio Nelson2
  • Vullo, Annamaria2
  • Innocenti, Giuseppe Pietro2
  • Mezzaroma, Ivano6
  • Mastroianni, Claudio Maria2
  • d'Ettorre, Gabriella2
  • 1 Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, 00161, Rome, Italy. [email protected] , (Italy)
  • 2 Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, 00161, Rome, Italy. , (Italy)
  • 3 Laboratory of Virology, Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy. , (Italy)
  • 4 Exercise Physiology Laboratory, Department of Physiology and Pharmacology, University of Rome Sapienza, Rome, Italy. , (Italy)
  • 5 Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome, Italy. , (Italy)
  • 6 Department of Clinical Medicine, University of Rome Sapienza, Rome, Italy. , (Italy)
Type
Published Article
Journal
AIDS and Behavior
Publisher
Springer-Verlag
Publication Date
Apr 01, 2020
Volume
24
Issue
4
Pages
1042–1050
Identifiers
DOI: 10.1007/s10461-019-02510-y
PMID: 31016505
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Several studies evidenced that a sedentary lifestyle is related with higher levels of systemic inflammation and highlighted that physical activity can trigger anti-inflammatory effects. To evaluate the impact of self-prescribed physical activity on fitness status, metabolism, inflammation and immune-activation in people living with HIV, an interim analysis of the results of the clinical trial PRIMO (NCT03392805) was performed. Patients enrolled were divided in 2 groups on the basis of self-prescribed physical activity: a physically active group (self-prescribed physical activity) and a sedentary group. Physical fitness was evaluated by sport medicine specialists and related to nutritional status, anthropometric variables, adipokines levels (adiponectin, leptin, resistin), peripheral immune-activation (CD38, HLA-DR on CD4 and CD8), and plasma inflammatory markers (IL-6 and TNF-α). The physically active group had a better profile in anthropometric measures and aerobic fitness but did not show lower levels of immune-activation compared to sedentary group. Also serum IL-6, TNF-α, and adipokines levels showed no statistical differences. On the basis of these data, a regular self-organized physical activity seems useful to improve cardio-respiratory fitness, but unable to control HIV-related immune-activation.

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