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Phylogeny of multidrug transporters.

Authors
Type
Published Article
Journal
Seminars in Cell and Developmental Biology
1084-9521
Publisher
Elsevier
Publication Date
Volume
12
Issue
3
Pages
205–213
Identifiers
PMID: 11428913
Source
Medline

Abstract

We currently recognize five large ubiquitous superfamilies and one small eukaryotic-specific family in which cellular multidrug efflux pumps occur. One, the ABC superfamily, includes members that use ATP hydrolysis to drive drug efflux, but the MFS, RND, MATE and DMT superfamilies include members that are secondary carriers, functioning by drug:H(+)or drug:Na(+)antiport mechanisms. The small MET family seems to be restricted to endosomal membranes of eukaryotes, and only a single such system has been functionally characterized. In this review article, these families of drug transporters are discussed and evaluated from phylogenetic standpoints.

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