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In Vitro and In Vivo Study of the Short-Term Vasomotor Response during Epileptic Seizures.

Authors
  • Volnova, Anna1, 2
  • Tsytsarev, Vassiliy3
  • Ptukha, Maria2
  • Inyushin, Mikhail4
  • 1 Biological Faculty, Saint Petersburg State University, St Petersburg 199034, Russia.
  • 2 Institute of Translational Biomedicine, Saint Petersburg State University, St Petersburg 199034, Russia.
  • 3 School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
  • 4 Department of Physiology, School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA.
Type
Published Article
Journal
Brain Sciences
Publisher
MDPI AG
Publication Date
Dec 07, 2020
Volume
10
Issue
12
Identifiers
DOI: 10.3390/brainsci10120942
PMID: 33297329
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Epilepsy remains one of the most common brain disorders, and the different types of epilepsy encompass a wide variety of physiological manifestations. Clinical and preclinical findings indicate that cerebral blood flow is usually focally increased at seizure onset, shortly after the beginning of ictal events. Nevertheless, many questions remain about the relationship between vasomotor changes in the epileptic foci and the epileptic behavior of neurons and astrocytes. To study this relationship, we performed a series of in vitro and in vivo experiments using the 4-aminopyridine model of epileptic seizures. It was found that in vitro pathological synchronization of neurons and the depolarization of astrocytes is accompanied by rapid short-term vasoconstriction, while in vivo vasodilation during the seizure prevails. We suggest that vasomotor activity during epileptic seizures is a correlate of the complex, self-sustained response that includes neuronal and astrocytic oscillations, and that underlies the clinical presentation of epilepsy.

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