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Photochemical C-H Amination of Ethers and Geminal Difunctionalization Reactions in One Pot.

Authors
  • Hernández-Guerra, Daniel1
  • Hlavačková, Anna1
  • Pramthaisong, Chiranan1
  • Vespoli, Ilaria1
  • Pohl, Radek1
  • Slanina, Tomáš1
  • Jahn, Ullrich1
  • 1 Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo námĕstí 2, 16610, Prague 6, Czech Republic. , (Czechia)
Type
Published Article
Journal
Angewandte Chemie International Edition in English
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 02, 2019
Volume
58
Issue
36
Pages
12440–12445
Identifiers
DOI: 10.1002/anie.201905209
PMID: 31233670
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A mild, atom-economic, and metal-free α-C-H amination of ethers using relatively stable nonafluorobutanesulfonyl (nonaflyl, Nf) azide as the aminating reagent to give N-sulfonyl hemiaminals is reported. This enables unprecedented C(sp3 ) difunctionalization reactions, leading to diverse functionalized amino group containing compounds starting from simple ethers in one pot. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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