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Phosphorylation-dependent regulation of messenger RNA transcription, processing and translation within biomolecular condensates.

Authors
  • Nosella, Michael L1
  • Forman-Kay, Julie D2
  • 1 Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. , (Canada)
  • 2 Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
Current opinion in cell biology
Publication Date
Jan 12, 2021
Volume
69
Pages
30–40
Identifiers
DOI: 10.1016/j.ceb.2020.12.007
PMID: 33450720
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Regulation of messenger RNA (mRNA) transcription, processing and translation occurs in the context of biomolecular condensates. How the physical properties of condensates connect with their biological regulatory functions is an ongoing area of interest, particularly for RNA metabolic pathways. Phosphorylation has emerged as an important mechanism for regulating protein phase separation propensities and localization patterns into different condensates, affecting compositions and dynamics. Key factors in transcription, mRNA processing and translation exhibit such phosphorylation-dependent changes in their roles within condensates, including their catalytic activities. Phosphorylation is increasingly understood to regulate the exchange of proteins through functionally linked condensates to fulfil their mRNA metabolic functions. Copyright © 2020 Elsevier Ltd. All rights reserved.

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