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Phosphorylation of S6 Protein as a Potential Biomarker in Surgically Treated Refractory Epilepsy

Authors
  • Chodraui, Felipe I.
  • Garcia, Camila Araújo B.
  • Mendes, Niele D.
  • Santos, Marcelo V.
  • Beggiora, Pâmela S.
  • Silva, Stephanya C.
  • Teixeira, Thiago L.
  • da Silva Lopes, Luiza
  • Saggioro, Fabiano P.
  • Neder, Luciano
  • Machado, Hélio R.
Type
Published Article
Journal
Developmental Neuroscience
Publisher
S. Karger AG
Publication Date
Mar 11, 2021
Volume
42
Issue
5-6
Pages
230–236
Identifiers
DOI: 10.1159/000514006
PMID: 33706310
Source
Karger
Keywords
License
Green
External links

Abstract

The tuberous sclerosis complex (TSC), focal cortical dysplasia IIB (FCD IIB), and hemimegalencephaly (HME) exhibit similar molecular features that are dependent on the hyperactivation of the mTOR pathway. They are all associated with refractory epilepsy and the need for surgical resection with varying outcomes. The phosphorylated protein S6 (pS6) is a downstream target of mTOR, whose increased expression might indicate mTOR hyperactivation, but which is also present when there is no alteration in the pathway (such as in FCD type I). We have performed immunohistochemical marking and quantification of pS6 in resected brain specimens of 26 patients clinically and histologically diagnosed with TSC, FCD IIB, or HME and compared this data to a control group of 25 patients, to measure the extent of pS6 positivity and its correlation with clinical aspects. Our results suggest that pS6 may serve as a reliable biomarker in epilepsy and that a greater percentage of pS6 marking can relate to more severe forms of mTOR-dependent brain anomalies.

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