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Phosphoprotein phosphatase-catalyzed dephosphorylation of the 22,000-dalton phosphoprotein of cardiac sarcoplasmic reticulum.

Authors
  • Kirchberger, M A
  • Raffo, A
Type
Published Article
Journal
Recent advances in studies on cardiac structure and metabolism
Publication Date
Jan 01, 1976
Volume
11
Pages
285–291
Identifiers
PMID: 201987
Source
Medline
License
Unknown

Abstract

Similar time courses were obtained for decreases in the rate of calcium transport by cardiac sarcoplasmic reticulum vesicles previously phosphorylated by cAMP-dependent protein kinase and dephosphorylation of the 22,000-dalton phosphoprotein in these membranes. Dephosphorylation of the 22,000-dalton phosphoprotein can be attributed to a phosphoprotein phosphatase in the sarcoplasmic reticular membranes. This membrane-bound phosphoprotein phosphatase may play a role in the reversal of the relaxation-promoting effect of catecholamines on the heart.

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