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Phospholipid modifications in bacteria.

Authors
  • Cronan, John E Jr
Type
Published Article
Journal
Current Opinion in Microbiology
Publisher
Elsevier
Publication Date
Apr 01, 2002
Volume
5
Issue
2
Pages
202–205
Identifiers
PMID: 11934618
Source
Medline
License
Unknown

Abstract

Many bacteria alter the acyl chains of their membrane phospholipids in response to changing environmental conditions. Two of these modifications are reviewed: cis-->trans isomerization and cyclopropanation of double bonds. The isomerization reaction is now known to be catalyzed by a periplasmic protein that contains a covalently bound heme. Cyclopropanation has been shown to play a role in Mycobacterium tuberculosis pathogenesis and, in Escherichia coli, plays an important role in resistance to acidic conditions.

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