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Phospholipase A in Gram-negative bacteria and its role in pathogenesis.

Authors
  • Istivan, Taghrid S
  • Coloe, Peter J
Type
Published Article
Journal
Microbiology (Reading, England)
Publication Date
May 01, 2006
Volume
152
Issue
Pt 5
Pages
1263–1274
Identifiers
PMID: 16622044
Source
Medline
License
Unknown

Abstract

Phospholipase A (PLA) is one of the few enzymes present in the outer membrane of Gram-negative bacteria, and is likely to be involved in the membrane disruption processes that occur during host cell invasion. Both secreted and membrane-bound phospholipase A(2) activities have been described in bacteria, fungi and protozoa. Recently there have been increasing reports on the involvement of PLA in bacterial invasion and pathogenesis. This review highlights the latest findings on PLA as a virulence factor in Gram-negative bacteria.

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