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Phospholipase A in Gram-negative bacteria and its role in pathogenesis.

Authors
Type
Published Article
Journal
Microbiology (Reading, England)
Publication Date
Volume
152
Issue
Pt 5
Pages
1263–1274
Identifiers
PMID: 16622044
Source
Medline

Abstract

Phospholipase A (PLA) is one of the few enzymes present in the outer membrane of Gram-negative bacteria, and is likely to be involved in the membrane disruption processes that occur during host cell invasion. Both secreted and membrane-bound phospholipase A(2) activities have been described in bacteria, fungi and protozoa. Recently there have been increasing reports on the involvement of PLA in bacterial invasion and pathogenesis. This review highlights the latest findings on PLA as a virulence factor in Gram-negative bacteria.

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