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The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy

Authors
  • Ravussin, Anthony1, 2
  • Brech, Andreas1, 2
  • Tooze, Sharon A.3
  • Stenmark, Harald1, 2
  • 1 University of Oslo, Faculty of Medicine, Montebello, 0379 Oslo , (Norway)
  • 2 Institute for Cancer Research, Oslo University Hospital, Department of Molecular Cell Biology, Montebello, 0379 Oslo , (Norway)
  • 3 The Francis Crick Institute, Molecular Cell Biology of Autophagy Laboratory, London NW1 1AT
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Feb 10, 2021
Volume
134
Issue
3
Identifiers
DOI: 10.1242/jcs.250670
PMID: 33468622
PMCID: PMC7888711
Source
PubMed Central
Keywords
License
Green

Abstract

Highlighted Article: The PI3P-binding protein SNX4 mediates recycling of the autophagy-promoting lipid scramblase ATG9A from lysosomes and autolysosomes, allowing reuse of this enzyme for rounds of autophagosome biogenesis.

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