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Phenytoin pharmacokinetics in the rabbit: evidence of rapid autoinduction.

Authors
  • Cusack, B J
  • Tesnohlidek, D A
  • Loseke, V L
  • Eggerth, R M
  • Olson, R D
Type
Published Article
Journal
Research communications in chemical pathology and pharmacology
Publication Date
Nov 01, 1987
Volume
58
Issue
2
Pages
269–272
Identifiers
PMID: 3423424
Source
Medline
License
Unknown

Abstract

Phenytoin pharmacokinetics were studied during continuous intravenous infusion in 12 New Zealand white rabbits. The mean clearance at 40 hours (5.1 +/- 1.1 ml/min per kg; mean +/- SE) was significantly greater than that at 16 hours (3.1 +/- 0.5 ml/min per kg; p less than 0.05). These data suggest that with chronic administration, autoinduction of metabolism results in an increase in the rate of phenytoin clearance in the rabbit.

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