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Phenotypic and molecular analyses of X-linked dystonia-parkinsonism ("lubag") in women.

Authors
  • Evidente, Virgilio Gerald H
  • Nolte, Dagmar
  • Niemann, Stephan
  • Advincula, Joel
  • Mayo, Mezzanie C
  • Natividad, Filipinas F
  • Müller, Ulrich
Type
Published Article
Journal
Archives of Neurology
Publisher
American Medical Association
Publication Date
Dec 01, 2004
Volume
61
Issue
12
Pages
1956–1959
Identifiers
PMID: 15596620
Source
Medline
License
Unknown

Abstract

The phenotypes of female patients with XDP may include parkinsonism, dystonia, myoclonus, tremor, and chorea. The dystonia, if present, is mild and usually nonprogressive. Similar to men with XDP, parkinsonism is a frequent symptom in women. In contrast to men, affected women have a more benign phenotype, older age of onset, and milder course. Extreme X-inactivation mosaic may be a cause of symptoms in women with XDP, but a homozygously affected woman has also been observed.

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