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[The phenomenon of tachyphylaxis in the pathogenesis of an experimental infectious process].

Authors
Type
Published Article
Journal
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
Publication Date
Issue
5-6
Pages
17–21
Identifiers
PMID: 1455961
Source
Medline

Abstract

Experiments on mice have revealed that the development of experimental purulent infection is accompanied by a considerable increase in the nonspecific resistance of the animals to additional infection with unrelated bacteria (the effect of tachyphylaxis). Morphologically, this is manifested by the rapid limitation of the focus of inflammation at the site of inoculation of the superinfecting agent. The state of the phagocytic apparatus is of great importance for this phenomenon as disturbances in the macrophage activity caused by the injection of carrageenan abolish the protective effect of primary infection. The phenomenon of tachyphylaxis has been shown to play a certain role in the prevention of the septic generalization of the process and in resistance to superinfection.

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