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PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.

Authors
  • ROSENKRANZ, H S
  • CARR, H S
  • ROSE, H M
Type
Published Article
Journal
Journal of bacteriology
Publication Date
May 01, 1965
Volume
89
Pages
1354–1369
Identifiers
PMID: 14293009
Source
Medline
Keywords
License
Unknown

Abstract

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), Howard S. Carr, and Harry M. Rose. Phenethyl alcohol. I. Effect on macromolecular synthesis of Escherichia coli. J. Bacteriol. 89:1354-1369. 1965.-An investigation of the mode of action of phenethyl alcohol produced the following results. Phenethyl alcohol had no effect on the physicochemical properties of isolated deoxyribonucleic acid (DNA). The DNA isolated from phenethyl alcohol-treated bacteria had physicochemical properties identical with those of DNA isolated from normal cells. The metabolic functions most sensitive to the inhibitory action of phenethyl alcohol appeared to be the process of enzyme induction and, possibly, the synthesis of messenger ribonucleic acid. Phenethyl alcohol did not affect the polyuridylic acid-mediated synthesis of polyphenylalanine in a cell-free amino acid-incorporating system.

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