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Phase Separation in Cell Division.

Authors
  • Ong, Joseph Y1
  • Torres, Jorge Z2
  • 1 Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • 2 Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: [email protected]
Type
Published Article
Journal
Molecular cell
Publication Date
Oct 01, 2020
Volume
80
Issue
1
Pages
9–20
Identifiers
DOI: 10.1016/j.molcel.2020.08.007
PMID: 32860741
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cell division requires the assembly and organization of a microtubule spindle for the proper separation of chromosomes in mitosis and meiosis. Phase separation is an emerging paradigm for understanding spatial and temporal regulation of a variety of cellular processes, including cell division. Phase-separated condensates have been recently discovered at many structures during cell division as a possible mechanism for properly localizing, organizing, and activating proteins involved in cell division. Here, we review how these condensates play roles in regulating microtubule density and organization and spindle assembly and function and in activating some of the key players in cell division. We conclude with perspectives on areas of future research for this exciting and rapidly advancing field. Copyright © 2020 Elsevier Inc. All rights reserved.

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