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Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.

Authors
  • Smorenburg, C H
  • Peters, G J
  • van Groeningen, C J
  • Noordhuis, P
  • Smid, K
  • van Riel, A M G H
  • Dercksen, W
  • Pinedo, H M
  • Giaccone, G
Type
Published Article
Journal
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Publication Date
Jan 01, 2006
Volume
17
Issue
1
Pages
35–42
Identifiers
PMID: 16251201
Source
Medline
License
Unknown

Abstract

Prospective selection of 5-FU/LV chemotherapy based on low TS and DPD expression in patients with ACRC did not confirm the high response rates reported in retrospective studies. The procedure of obtaining metastatic tissue and quantitation of enzymes appeared feasible but cumbersome. Before assessing the clinical utility of a predictive marker in a randomized trial, future studies should focus on prospective validation of the assay in a large and well defined population.

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