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[Phase II study of 4'-O-tetrahydropyranyl-adriamycin (THP-ADM) in patients with gynecological cancer].

Authors
  • Kato, T
  • Nishimura, H
  • Umezu, J
  • Takeuchi, S
  • Kanazawa, K
  • Inoue, H
  • Suzuki, M
  • Hirono, M
  • Suzuki, T
  • Okajima, H
Type
Published Article
Journal
Gan to kagaku ryoho. Cancer & chemotherapy
Publication Date
Oct 01, 1985
Volume
12
Issue
10
Pages
1962–1967
Identifiers
PMID: 4051511
Source
Medline
License
Unknown

Abstract

We conducted a joint phase II study in 76 patients with gynecological cancer (42 patients with ovarian cancer, 22 patients with cervical cancer, 10 patients with endometrial cancer and 2 patients with vaginal cancer). The response rate was 25.0% in the patients with ovarian cancer, 13.3% in those with cervical cancer, and 28.6% in those with endometrial cancer. The overall response rate was 23.1%. When the patients were classified according to dose schedules, the highest response rate was obtained in the group administered THP-ADM at a dose of 60 mg per body by single i.v. injection at 3-week intervals. Such side effects as myelosuppression and gastrointestinal disturbances were observed, but alopecia, a marked side-effect of ADM administration, was mild, and no cardiac toxicity was seen in any of the patients.

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