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Phase I study of pemetrexed and pegylated liposomal doxorubicin in patients with refractory breast, ovarian, primary peritoneal, or fallopian tube cancer.

Authors
Type
Published Article
Journal
Investigational New Drugs
1573-0646
Publisher
Springer-Verlag
Publication Date
Volume
29
Issue
5
Pages
963–970
Identifiers
DOI: 10.1007/s10637-010-9414-6
PMID: 20352294
Source
Medline
License
Unknown

Abstract

Pemetrexed plus PLD was reasonably tolerated in this heavily-pretreated population. MTD: pemetrexed 500 mg/m(2) and PLD 40 mg/m(2) may be carried forward to phase II studies in specific patient populations. TTP in platinum-refractory ovarian patients was greater than expected.

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