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A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors.

Authors
  • Dickson, Mark Andrew
  • Rathkopf, Dana E
  • Carvajal, Richard D
  • Grant, Steven
  • Roberts, John D
  • Reid, Joel M
  • Ames, Matthew M
  • McGovern, Renee M
  • Lefkowitz, Robert A
  • Gonen, Mithat
  • Cane, Lauren M
  • Dials, Heather J
  • Schwartz, Gary K
Type
Published Article
Journal
Investigational New Drugs
Publisher
Springer-Verlag
Publication Date
Oct 01, 2011
Volume
29
Issue
5
Pages
1004–1012
Identifiers
DOI: 10.1007/s10637-010-9447-x
PMID: 20461440
Source
Medline
License
Unknown

Abstract

Intermittent high dose oral V in combination with F is feasible and achieves target serum levels >2.5 µM. V concentrations higher than previously reported with oral dosing were achieved.

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