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Phase Diagram and Estimation of Flory-Huggins Parameter of Interaction of Silk Fibroin/Sodium Alginate Blends

Authors
  • Lopes, Laise Maia1
  • de Moraes, Mariana Agostini2
  • Beppu, Marisa Masumi1
  • 1 School of Chemical Engineering, University of Campinas, Campinas , (Brazil)
  • 2 Department of Chemical Engineering, Federal University of São Paulo, Diadema , (Brazil)
Type
Published Article
Journal
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Publication Date
Aug 18, 2020
Volume
8
Identifiers
DOI: 10.3389/fbioe.2020.00973
PMID: 33014999
PMCID: PMC7461969
Source
PubMed Central
Keywords
License
Unknown

Abstract

Silk fibroin (SF) and sodium alginate (SA) are natural polymers used to produce biomaterials. One of the strategies to improve the properties of these products is to prepare blends with them, which are partially miscible. Phase separation is observed, therefore, the thermodynamic analysis of this system is important to predict the final state and composition of this blends. This study explored blends with a different initial composition of SF, SA, and water (WA) at 25°C and neutral pH. After phase separation, two phases were identified, one rich in SF and other rich in SA. The Flory-Huggins parameters of interaction of polymer-solvent and polymer-polymer were estimated using the extended equation and data of phase equilibrium, their values indicates the partial miscibility of the polymers.

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