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Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy

Authors
  • Kern, Karsten1, 2
  • Lukmann, Fania1
  • Obreja, Karina1
  • Al-Maawi, Sara3
  • Carla, Bellinghausen4
  • Ghanaati, Shahram3
  • Rohde, Gernot4
  • Sader, Robert3
  • Schwarz, Frank1
  • 1 Goethe University, Carolinum, Frankfurt, Germany , Frankfurt (Germany)
  • 2 Knappschaftskrankenhaus, Sulzbach, Germany , Sulzbach (Germany)
  • 3 Medical Center of the Goethe University Frankfurt, Frankfurt, Germany , Frankfurt (Germany)
  • 4 Goethe University, Frankfurt, Germany , Frankfurt (Germany)
Type
Published Article
Journal
International Journal of Implant Dentistry
Publisher
Springer Berlin Heidelberg
Publication Date
Jun 03, 2021
Volume
7
Issue
1
Identifiers
DOI: 10.1186/s40729-021-00332-z
Source
Springer Nature
Keywords
License
Green

Abstract

ObjectivesTo assess the influence of antiresorptive/antiangiogenic therapy on the spreading of peri-implant infections in the pharyngeal region.Material and methodsThis analysis was based on tissue biopsies obtained from a total of twenty-five albino rats having either received (1) amino-bisphosphonate (Zoledronate) (Zo) (n=4), (2) RANKL inhibitor (Denosumab) (De) (n=4), (3) antiangiogenic medication (Bevacizumab) (Be) (n=4), (4) Zo+Be (n=3), (5) De+Be (n=5), or (6) no medication (Co) (n=5). Drug administration was repeated at 12 weeks. Chronic-type peri-implant infections were induced at titanium implants located in the upper jaws. The surface area (%) of infiltrated connective tissue (ICT) and CD68-positive cells was assessed within the lateral pharyngeal/retropharyngeal connective tissue zone.ResultsMean (±SD) and median ICT% values and CD68 counts were markedly highest in the De+Be (11.10±6.04; 11.81; 95% CI − 3.89; 26.11) and De (5.70±5.06; 6.19; 95% CI − 2.34; 13.75) groups, reaching statistical significance for De CD68 counts over the Co (0.18±0.25; 0.18; 95% CI −2.14; 2.51) group. In both De+Be and De groups, the ICTs were occasionally associated with an ulceration of the epithelial compartment.ConclusionsInduced peri-implant infections were not associated with any inflammatory lesions in pharyngeal tissues. While these findings were similar under Zo and Be medication, De and De+Be had a marked effect on ICT and CD68 values. The clinical relevance of these adverse findings needs further investigation.

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