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Pharmacotherapy for hypertension in adults aged 18 to 59 years.

Authors
  • Musini, Vijaya M1
  • Gueyffier, Francois
  • Puil, Lorri
  • Salzwedel, Douglas M
  • Wright, James M
  • 1 Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Science Mall, Vancouver, BC, Canada, V6T 1Z3. , (Canada)
Type
Published Article
Journal
The Cochrane database of systematic reviews
Publication Date
Aug 16, 2017
Volume
8
Identifiers
DOI: 10.1002/14651858.CD008276.pub2
PMID: 28813123
Source
Medline
License
Unknown

Abstract

Antihypertensive drugs used to treat predominantly healthy adults aged 18 to 59 years with mild to moderate primary hypertension have a small absolute effect to reduce cardiovascular mortality and morbidity primarily due to reduction in cerebrovascular mortality and morbidity. All-cause mortality and coronary heart disease were not reduced. There is lack of good evidence on withdrawal due to adverse events. Future trials in this age group should be at least 10 years in duration and should compare different first-line drug classes and strategies.

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