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[Pharmacological treatment options for prevention of alcohol relapse].

Authors
Type
Published Article
Journal
Fortschritte der Neurologie-Psychiatrie
Publication Date
Volume
76
Issue
7
Pages
421–428
Identifiers
DOI: 10.1055/s-2008-1038220
PMID: 18604776
Source
Medline
License
Unknown

Abstract

Many studies address the neurobiological mechanisms of alcohol craving. The study results obtained so far show that there may be at least three subtypes of craving, which may be linked to changes in different neurotransmitter systems. Actually in Germany acamprosate and disulfiram are approved for clinical use for the prevention of alcohol relapse. Also off-label therapy with naltrexone is possible. However studies show that these substances are not effective in all patients. In the light of hypothetical changes in different neurotransmitter systems, subtype specific therapy may be necessary for successful prevention of alcohol relapse. Therefore new therapy options are needed in order to treat alcohol dependent persons. Substances that seem to have efficacy in preclinical or preliminary clinical studies are baclofen, topiramate, odansetron, rimonabant and memantine.

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