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The pharmacological treatment of delusional depression.

Authors
Type
Published Article
Journal
The American journal of psychiatry
Publication Date
Volume
142
Issue
4
Pages
430–436
Identifiers
PMID: 3883815
Source
Medline
License
Unknown

Abstract

The authors investigated the pharmacological treatment of delusional depression by assigning patients on a random double-blind basis to amitriptyline alone, perphenazine alone, or a combination of the two. Fourteen (78%) of the 18 patients assigned to amitriptyline plus perphenazine were responders, compared with seven (41%) of 17 patients treated with amitriptyline alone and three (19%) of the 16 patients treated with perphenazine alone. The combination of amitriptyline and perphenazine was clearly superior (p less than .01).

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