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Pharmacological prophylaxis in the kindling model of epilepsy.

Authors
  • Wada, J A
Type
Published Article
Journal
Archives of Neurology
Publisher
American Medical Association
Publication Date
Jul 01, 1977
Volume
34
Issue
7
Pages
389–395
Identifiers
PMID: 406881
Source
Medline
License
Unknown

Abstract

Review of antiepileptic drug assessment to date by means of the kindling model of epilepsy suggests that it fills a gap that is evident in standard screening methods such as maximum electroshock or pentylenetetrazol screening tests. However, in order to obtain a comprehensive profile of antiepileptic drugs regarding prophylaxis of developing seizures and treatment of well-established seizures through the kindling preparation, it is desirable to have the following: (1) standardization of kindling techniques, (2) examination of drug effects on developing as opposed to developed seizures, (3) use of a variety of animal species, involving different functional brain sites, and (4) monitoring of plasma levels of the drug administered. It is envisaged that judicious use of the kindling preparation might also enable us to gain some insight into the mechanisms by which drugs produce their prophylactic or therapeutic effect.

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