In summary it appears that beta 2-blockade does not lower high blood pressure. Beta 1-blockade seems to be the necessary feature for the antihypertensive effect. Beta 1 ISA may attenuate the blood pressure lowering efficacy. Finally beta 2 ISA causes a favourable hemodynamic pattern in which the blood pressure lowering occurs mainly through vasodilatation. The ideal beta-blocker for hypertension should cause beta 1-blockade. It should not cause beta 2-blockade and it should possess relatively pronounced beta 2 ISA.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 07/01/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2859741