Pharmacological properties of beta-adrenoceptor blockers in relation to their antihypertensive effect.
- Published Article
Acta medica Scandinavica. Supplementum
- Publication Date
Jan 01, 1985
In summary it appears that beta 2-blockade does not lower high blood pressure. Beta 1-blockade seems to be the necessary feature for the antihypertensive effect. Beta 1 ISA may attenuate the blood pressure lowering efficacy. Finally beta 2 ISA causes a favourable hemodynamic pattern in which the blood pressure lowering occurs mainly through vasodilatation. The ideal beta-blocker for hypertension should cause beta 1-blockade. It should not cause beta 2-blockade and it should possess relatively pronounced beta 2 ISA.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2859741