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Pharmacological profiles of tonazocine (Win 42156) and zenazocine (Win 42964).

Authors
  • Ward, S J
  • Pierson, A K
  • Michne, W F
Type
Published Article
Journal
Neuropeptides
Publication Date
Feb 01, 1985
Volume
5
Issue
4-6
Pages
375–378
Identifiers
PMID: 2860595
Source
Medline
License
Unknown

Abstract

The effects of tonazocine and zenazocine, two mixed agonist/antagonist analgesics, have been evaluated in a range of antinociceptive assays and in isolated tissue preparations in vitro. Both tonazocine and zenazocine were antinociceptive in writhing tests and in the i.a. bradykinin test, and were antagonists in the rat tail flick test. Additionally, zenazocine demonstrated some antinociceptive activity in the rat tail flick test. In vitro, both tonazocine and zenazocine demonstrated agonist and antagonist properties at mu receptors in the GPI and agonist properties at delta receptors in the MVD. In general, the agonist properties of zenazocine were more marked than those of tonazocine, and the antagonist properties of tonazocine were more marked than those of zenazocine.

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