Affordable Access

Pharmacological profile of neuroleptics at human monoamine transporters.

Authors
  • Tatsumi, M
  • Jansen, K
  • Blakely, R D
  • Richelson, E
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Mar 05, 1999
Volume
368
Issue
2-3
Pages
277–283
Identifiers
PMID: 10193665
Source
Medline
License
Unknown

Abstract

Using radioligand binding techniques, we determined the equilibrium dissociation constants (K(D)) for 37 neuroleptics and one metabolite of a neuroleptic (haloperidol metabolite) for the human serotonin, norepinephrine, and dopamine transporters with [3H]imipramine, [3H]nisoxetine, and [3H]WIN35428, respectively. Among neuroleptics, the four most potent compounds at the human serotonin transporter were triflupromazine, fluperlapine, chlorpromazine, and ziprasidone (K(D) 24-39 nM); and at the norepinephrine transporter, chlorpromazine, zotepine, chlorprothixene, and promazine (K(D) 19-25 nM). At the human dopamine transporter, only pimozide (K(D) = 69+/-3) ziprasidone (K(D) = 76+/-5) had notable potency. These data may be useful in predicting therapeutic and adverse effects, including drug interactions of neuroleptics.

Report this publication

Statistics

Seen <100 times