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[Pharmacological mechanism analysis of oligopeptide from Pinctada fucata based on in silico proteolysis and protein interaction network].

Authors
  • Duan, Jin-Long1
  • Yao, Kui-Wu1
  • Feng, Xiao-Xiao1
  • Cao, Jue1, 2
  • Yu, Zhou1
  • 1 Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. , (China)
  • 2 Beijing University of Chinese Medicine, Beijing 100029, China. , (China)
Type
Published Article
Journal
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Publication Date
Sep 01, 2017
Volume
42
Issue
17
Pages
3424–3429
Identifiers
DOI: 10.19540/j.cnki.cjcmm.20170731.009
PMID: 29192457
Source
Medline
Keywords
License
Unknown

Abstract

Thoracic obstruction is mainly attributed to the scope of coronary heart disease in modern medicine, and traditional Chinese medicine(TCM) shows a significant effect in the treatment of thoracic obstruction. In this research, a network pharmacology method was carried out to systemically study the underlying mechanism of the core herbal compatibility in TCM on the thoracic obstruction. First, we collected the literature about TCM prescriptions for treating thoracic obstruction from CNKI. Then, a prescription database was establish by TCM inheritance support platform system(V2.5) to determine the medication rules and core herbal compatibility in TCM. Finally, to obtain the potential signaling pathways, KEGG pathway analysis was performed by BATMAN-TCM online analysis tool. Results showed that the potential signal pathway of core herbal compatibility in TCM for the clinical treatment of thoracic obstruction was calcium ion and cGMP-PKG signaling pathway. This study provided a new research strategy for the study of the medication rules and mechanism of traditional Chinese medicine in the treatment of thoracic obstruction.

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