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Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti

Authors
  • Trigueros, Renata Rusconi
  • Hopkins, Corey R.
  • Denton, Jerod S.
  • Piermarini, Peter M.
Publication Date
Nov 15, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

and (2) the disruption of osmoregulation as a potential mechanism of the toxic action of VU041. The present study provides the first evidence that inhibition of Kir channels is lethal to larval mosquitoes and broadens the potential applications of our existing arsenal of small molecule inhibitors of Kir channels, which have previously only been considered for developing adulticides.

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