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[Pharmacological analysis of the ontogenetic traits of the functional receptor activity of glial and neuronal GABA uptake and GABA-T activity in the rat hippocampus].

Authors
  • Kozlovskiĭ, V L
Type
Published Article
Journal
Zhurnal evoliutsionnoĭ biokhimii i fiziologii
Publication Date
Jan 01, 1986
Volume
22
Issue
6
Pages
543–547
Identifiers
PMID: 3030028
Source
Medline
License
Unknown

Abstract

Studies have been made on the effect of GABA mimetics on epileptogenic focus in the hippocamp of growing rats. By the pattern of inhibition of this focus by these drugs, it is possible to evaluate the degree of functional maturation of the activity of GABA receptors, glial and neuronal uptake of GABA, and the activity of GABA-T. Higher sensitivity of GABA receptors in younger animals was found together with a higher functional role of glial uptake in GABA utilization. Functional activity of GABA-T and neuronal uptake of the mediator are of lower physiological significance in younger animals as compared to those in adults.

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