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Pharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils.

Authors
  • de Sousa, Damião P
  • Nóbrega, Franklin F F
  • de Lima, Maria R V
  • de Almeida, Reinaldo N
Type
Published Article
Journal
Zeitschrift für Naturforschung. C, Journal of biosciences
Publication Date
Jan 01, 2011
Volume
66
Issue
7-8
Pages
353–359
Identifiers
PMID: 21950159
Source
Medline
License
Unknown

Abstract

(R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a significant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also significantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug.

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