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Pharmacologic thromboprophylaxis is a risk factor for hemorrhage progression in a subset of patients with traumatic brain injury.

Authors
  • Levy, Andrew Stewart
  • Salottolo, Kristin
  • Bar-Or, Raphael
  • Offner, Patrick
  • Mains, Charles
  • Sullivan, Michael
  • Bar-Or, David
Type
Published Article
Journal
Journal of Trauma and Acute Care Surgery
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Apr 01, 2010
Volume
68
Issue
4
Pages
886–894
Identifiers
DOI: 10.1097/TA.0b013e3181d27dd5
PMID: 20386284
Source
Medline
License
Unknown

Abstract

These findings suggest that PTP use is associated with a 13-fold increased odds of further hemorrhage progression in patients whose F/U CT within 1 day of admission showed ICH progression; 16% of this risk can be attributed to receiving PTP. Conversely, PTP may be safe in a subgroup of patients with TBI with no ICH progression on initial F/U CT.

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