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Pharmacologic assessment of the functional state in stenosed coronary circulation of the dog.

Authors
  • Kékesi, V
  • Juhász-Nagy, A
Type
Published Article
Journal
Acta physiologica Academiae Scientiarum Hungaricae
Publication Date
Jan 01, 1982
Volume
59
Issue
2
Pages
147–153
Identifiers
PMID: 7158369
Source
Medline
License
Unknown

Abstract

In open chest dogs under sodium pentobarbital anaesthesia the interaction of mechanical constriction on a large coronary branch and autoregulatory capacity of the relevant small resistance vessels was analyzed. Coronary blood flow (CBF) was measured with an electromagnetic flowmeter. Step-by-step mechanical constriction gradually abolished adenosine-induced coronary vasodilation, whereas the resting level of mean CBF remained unaltered. At this point verapamil (0.2 mg/kg i.v.), a vasodilator with a strong potency of blocking adenosine action, eventually decreased CBF and increased coronary resistance. Similar results were obtained with these drugs injected directly into a bypass established between the carotid and left common coronary arteries. The results suggest that (i) adenosine affects the same coronary segments which accomplish compensatory autoregulation (ii); with critical stenosis verapamil augments indirectly coronary resistance by inhibiting an "intrinsic" adenosine effect (iii); the functional state of stenosed coronaries can be assessed with the aid of these pharmacologic tests.

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