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The pharmacokinetics of oxycodone after intravenous injection in adults.

Authors
  • Pöyhiä, R
  • Olkkola, K T
  • Seppälä, T
  • Kalso, E
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
Oct 01, 1991
Volume
32
Issue
4
Pages
516–518
Identifiers
PMID: 1958450
Source
Medline
License
Unknown

Abstract

Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also measured. The mean AUC(0,12) ratio of noroxycodone to oxycodone was 0.33. Oxymorphone was not detected.

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