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Pharmacokinetics of Itraconazole Oral Solution in Neutropenic Children during Long-Term Prophylaxis

Authors
  • Claudine Schmitt
  • Yves Perel
  • Jean-luc Harousseau
  • Sophie Lemerle
  • Elisabeth Chwetzoff
  • Jean-Pierre le Moing
  • Jean-Claude Levron
Publisher
American Society for Microbiology
Publication Date
May 01, 2001
Source
PMC
Keywords
Disciplines
  • Pharmacology
License
Unknown

Abstract

We investigated the pharmacokinetics and safety of an oral solution of itraconazole in two groups of neutropenic children stratified by age. Effective concentrations of itraconazole in plasma were reached quickly and maintained throughout treatment. The results indicate a trend toward higher concentrations of itraconazole in plasma in older children.

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