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Pharmacokinetics of methotrexate in the extracellular fluid of brain C6-glioma after intravenous infusion in rats.

Authors
  • Dukic, S
  • Heurtaux, T
  • Kaltenbach, M L
  • Hoizey, G
  • Lallemand, A
  • Gourdier, B
  • Vistelle, R
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Aug 01, 1999
Volume
16
Issue
8
Pages
1219–1225
Identifiers
PMID: 10468023
Source
Medline
License
Unknown

Abstract

High plasma concentrations promote the penetration of MTX into brain tissue. However, free MTX concentrations in tumor ECF remain difficult to predict consistently.

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