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Pharmacokinetics of intraperitoneal gemcitabine in a rat model.

Authors
  • Pestieau, S R
  • Stuart, O A
  • Chang, D
  • Jacquet, P
  • Sugarbaker, P H
Type
Published Article
Journal
Tumori
Publication Date
Jan 01, 1998
Volume
84
Issue
6
Pages
706–711
Identifiers
PMID: 10080682
Source
Medline
License
Unknown

Abstract

These experiments demonstrated that the exposure of peritoneal surfaces to gemcitabine is significantly increased with i.p. gemcitabine. Intraabdominal hyperthermia had no significant effect on the pharmacokinetics of i.p. gemcitabine but there was evidence of increased absorption of gemcitabine in most intraabdominal tissues. Due to the likelihood of a high incidence of microscopic residual disease after resection of a pancreatic carcinoma, clinical studies to evaluate i.p. hyperthermic gemcitabine may be indicated.

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