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Pharmacokinetics and expert systems as aids for risk assessment in reproductive toxicology.

Authors
  • Mattison, D R
  • Jelovsek, F R
Type
Published Article
Journal
Environmental health perspectives
Publication Date
Dec 01, 1987
Volume
76
Pages
107–119
Identifiers
PMID: 3447888
Source
Medline
License
Unknown

Abstract

A minimal approach to risk assessment in reproductive toxicology involves four components: hazard identification, hazard characterization, exposure characterization, and risk characterization. In practice, risk assessment in reproductive toxicology has been reduced to arbitrary safety factors or mathematical models of the dose-response relationship. These approaches obscure biological differences across species rather than using this important and frequently accessible information. Two approaches that are formally capable of using biologically relevant information (pharmacokinetics and expert system shells) are explored as aids to risk assessment in reproductive toxicology.

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