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Pharmacokinetics of erythromycin in patients with different degrees of renal impairment.

Authors
  • Disse, B
  • Gundert-Remy, U
  • Weber, E
  • Andrassy, K
  • Sietzen, W
  • Lang, A
Type
Published Article
Journal
International journal of clinical pharmacology, therapy, and toxicology
Publication Date
Sep 01, 1986
Volume
24
Issue
9
Pages
460–464
Identifiers
PMID: 3781679
Source
Medline
License
Unknown

Abstract

The kinetics of erythromycin (E.) was studied in 16 patients with different degrees of impairment of renal function after a single intravenous dose. Renal clearance of E. was found to be significantly correlated to the creatinine clearance. Total recovery in urine did not exceed 7.5%. As expected from the small fraction excreted via the kidneys, the elimination half-life and the total clearance of E. did not depend on renal function. We conclude that impairment of renal function does not justify a dose adjustment of E. Hearing acuity should, however, be monitored during treatment since transient deafness predominantly in patients with renal failure has been reported by various authors.

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