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Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study.

Authors
  • de Lucas, J J
  • Rodríguez, C
  • Martella, M B
  • Lábaque, M C
  • Navarro, J L
  • San Andrés, M I
Type
Published Article
Journal
Research in Veterinary Science
Publisher
Elsevier
Publication Date
Jun 01, 2005
Volume
78
Issue
3
Pages
265–267
Identifiers
PMID: 15766947
Source
Medline
License
Unknown

Abstract

The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (V(ss)=5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t(1/2beta)=2.66 h and MRT=1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR+CIP).

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