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Pharmacokinetics of ceftazidime and cefepime in burn patients: the importance of age and creatinine clearance.

Authors
  • Conil, J M
  • Georges, B
  • Lavit, M
  • Seguin, T
  • Tack, I
  • Samii, K
  • Chabanon, G
  • Houin, G
  • Saivin, S
Type
Published Article
Journal
International journal of clinical pharmacology and therapeutics
Publication Date
Oct 01, 2007
Volume
45
Issue
10
Pages
529–538
Identifiers
PMID: 17966838
Source
Medline
License
Unknown

Abstract

In burn patients, the pharmacokinetic disposition of CF and CE was much more variable than in healthy subjects. Age and CL(CR) were predictors of the disposition of these antibiotics. Shortening the dosage interval or using continuous infusions will prevent low serum levels and keep trough levels above the MIC for longer periods of time. In view of the lack of a bedside measurement technique for ceftazidime and cefepime levels, we suggest a more frequent use of measured CL(CR) in order to attain efficacious clinical concentrations.

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