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Pharmacokinetics and bioavailability of an integrase and novel pharmacoenhancer-containing single-tablet fixed-dose combination regimen for the treatment of HIV.

Authors
  • German, Polina
  • Warren, David
  • West, Steve
  • Hui, James
  • Kearney, Brian P
Type
Published Article
Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Nov 01, 2010
Volume
55
Issue
3
Pages
323–329
Identifiers
DOI: 10.1097/QAI.0b013e3181eb376b
PMID: 20683270
Source
Medline
License
Unknown

Abstract

Fixed-dose combination tablet containing COBI 150 mg resulted in desired high EVG Ctau concentrations and clinically equivalent tenofovir and FTC exposures relative to currently approved individual agents and was thus selected for subsequent evaluation.

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