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Pharmacokinetics of anthracyclines in dogs: evidence for structure-related body distribution and reduction to their hydroxy metabolites.

Authors
  • Oosterbaan, M J1
  • Dirks, R J
  • Vree, T B
  • van der Kleijn, E
  • 1 Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, Nijmegen, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Jan 01, 1984
Volume
1
Issue
1
Pages
33–38
Identifiers
DOI: 10.1023/A:1016378609450
PMID: 24277182
Source
Medline
License
Unknown

Abstract

The pharmacokinetic disposition of the anthracyclines, adriamycin (doxorubicin), daunorubicin, 4'-epi-adriamycin, carminomycin, and 4-demethoxy-daunorubicin, and the formation of their reduced C13 hydroxy metabolites were studied in dogs. The presence of a C14hydroxy group (adriamycin and 4'epi-adriamycin) drastically reduces the appearance of the C13 hydroxy metabolites in plasma. Substitution of the C4-H with C4-OH and C4-OCH3, in this rank order, decreases the area under the plasma concentration-time curves of the parent compounds and their C13 hydroxy metabolites.

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