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Pharmacokinetic/pharmacodynamic parameters for treatment optimization of infection due to antibiotic resistant bacteria: a summary for practical purposes in children and adults.

Authors
  • Gustinetti, Giulia1
  • Cangemi, Giuliana2
  • Bandettini, Roberto2
  • Castagnola, Elio2
  • 1 a Department of Infectious Diseases , University of Genoa , Genoa , Italy. , (Italy)
  • 2 b Istituto Giannina Gaslini, Children's Hospital , Genoa , Italy. , (Italy)
Type
Published Article
Journal
Journal of chemotherapy (Florence, Italy)
Publication Date
Oct 13, 2017
Pages
1–17
Identifiers
DOI: 10.1080/1120009X.2017.1377909
PMID: 29025364
Source
Medline
Keywords
License
Unknown

Abstract

In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens. These parameters are available at least for the adult population, but sparse in many different publications. This review wants to provide a comprehensive and 'easy to read' text for everyday practice, briefly summarizing the presently available knowledge on pharmacokinetic/pharmacodynamic parameters (normalized for minimal inhibitory concentration values) of different class drugs, that can be applied for an effective antibacterial treatment infections due to antibiotic-resistant pathogens.

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