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Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration

Authors
  • van den Berg, JP
  • Vereecke, HEM
  • Proost, JH
  • Eleveld, DJ
  • Wietasch, JKG
  • Absalom, AR
  • Struys, Michel
Publication Date
Jan 01, 2017
Source
Ghent University Institutional Archive
Keywords
License
Unknown
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Abstract

This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.

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