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Pharmacokinetic and pharmacodynamic characteristics of aranidipine sustained-release, enteric-coated tablets in healthy Chinese men: a phase I, randomized, open-label, single- and multiple-dose study.

Authors
  • Jiang, Juanjuan
  • Tian, Lei
  • Huang, Yiling
  • Li, Yishi
  • Xu, Li
Type
Published Article
Journal
Clinical Therapeutics
Publisher
Elsevier
Publication Date
Jul 01, 2008
Volume
30
Issue
7
Pages
1290–1299
Identifiers
PMID: 18691988
Source
Medline
License
Unknown

Abstract

The results of this small study in healthy Chinese men suggest that the PK properties of aranidipine were linear with respect to dose, whereas the PK properties of the active M-1 metabolite were not fully linear. There was no apparent accumulation of aranidipine or M-1 with administration of single and multiple doses. Aranidipine was generally well tolerated.

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