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Pharmacokinetic evaluation of enrofloxacin in chickens.

Authors
  • Abd el-Aziz, M I
  • Aziz, M A
  • Soliman, F A
  • Afify, N A
Type
Published Article
Journal
British poultry science
Publication Date
May 01, 1997
Volume
38
Issue
2
Pages
164–168
Identifiers
PMID: 9158891
Source
Medline
License
Unknown

Abstract

1. The pharmacokinetics and bioavailability of enrofloxacin in chickens were investigated following intravenous, intramuscular, subcutaneous and oral administration of 10 mg/kg body weight. A rapid distribution phase was followed by a slower elimination phase. 2. The apparent volume of distribution was 2.2 l/kg. Absorption half lives were 0.37, 0.36 and 0.92 h; elimination half lives were 4.06, 4.48 and 4.29 h and bioavailabilities were 87.5%, 80.8% and 59.6% after intramuscular, subcutaneous and oral administration, respectively. The drug completely disappeared from all tissues after 3 days following oral administration. 3. Based on the bioavailability and disposition kinetics of enrofloxacin, administration of one dose per day should both be practical and adequate to maintain plasma enrofloxacin concentrations within the pharmacologically active but lower than tolerance limit.

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